American actress Sigourney Weaver is going to play the queen of the vampires in the horror comedy Vamps, trade magazine The Hollywood Reporter said.

Written and directed by Amy Heckerling (Look Who’s Talking, Clueless), this comedy follows two vampirettes (Alicia Silverstone and Krysten Ritter) through the New York club scene where they fall in love with human boys, putting at risk their immortality.

Weaver, 60, will play the part of Ciccerus, the bloodthirsty queen of the vampires, who is responsible for the young heroines’ transformation into creatures of the night. Filming is supposed to begin in April.

Recently seen in Avatar, James Cameron’s phenomenon, Weaver won fame in the role of Ellen Ripley in the chilling Alien series. She received an Oscar nomination in 1986 for the second film in the series, which was directed by Cameron.

In 1988, she won two Oscars, for best actress in Gorillas in the Mist and best supporting actress for Working Girl.